Since the time of formulation of quantum mechanics in the 1920s, there have been dissenting voices regarding its interpretation and meaning. Topics for discussion include, to name just a few, the nature of measurement, the transition between quantum and classical mechanics, and the question of whether or not quantum mechanics is a complete theory that comprehensively describes physical reality.

Currently, the research lines of this area at the Institute focus on a deeper understanding of the quantum phenomenon, and include: (a) The development of a rigorous theoretical framework that, by considering the quantum phenomenon as an emergent property of the interaction of matter with the radiation field, offers a physical basis for the postulates of conventional theory; (b) An analytically exact, non-Hermitian formulation of the time-dependent solutions of the Schrödinger equation in problems of quantum decay and transitory effects and their application to artificial quantum systems; (c) Studies of the notion of time in quantum mechanics that include, among others, relativistic aspects in the formulation of a time operator in quantum mechanics; (d) The measurement problem in quantum mechanics using the von Neumann model and its relationship with the Wigner function in phase space of position and moment.